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Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS FAR 5011 GENERAL PHARMACOLOGY COMPULSORY 2 0 0 8

Offered By

Pharmacology

Level of Course Unit

Second Cycle Programmes (Master's Degree)

Course Coordinator

PROFESSOR DOCTOR MUALLA AYLIN ARICI

Offered to

Pharmacology Toxicology CLINICAL DRUG RESEARCH Laboratory Medicine TRANSLATIONAL MEDICINE

Course Objective

To learn general aspects of drugs, to discuss pharmacokinetics and pharmacodynamics of drugs, to discuss mechanism of drug-drug interactions

Learning Outcomes of the Course Unit

1   to define drug absorption, to classify and explain the factors which affects absorption rate of drugs, to discuss effects of food on drug absorption, to explain diffusion of drugs from membranes, to define bioavailabilty, to define entero-hepatic cycle. 2   to relate the molecular structure of drugs with physiologic fluid compartments; to define free and bound drug; to define secestration; to define redistribution; to define and to interpret volume of distribution; 3   to discuss the results of drugs metabolism; to explain phase I and phase II metabolism and the general properties of enzymes that play a role in metabolism; to interpret the role of microsomal enzymes in drug-drug interactions; to discuss hepatic clearance; 4   to explain the renal elimination mechanisms of drugs; to explain general properties of drugs eliminated by renal; to know about other elimination ways and general properties of drugs eliminated by these ways; to explain the concept of total clearance and renal clearance; to interpret kinetics and elimination half life of drugs 5   to explain and interpret the factors which change the effects of drugs. 6   to describe the mechanism of effects of drugs 7   to describe and explain the mechanisms of drug-drug interaction and drug-food interaction 8   to draw graphs of the blood versus time for drugs and to explain basic pharmacokinetic parameters (Cmax, tmax, t1/2, EAA, Cl, ke); to describe drug concentration-effect relationships and to explain basic pharmacodynamic parameters (Emax, EC50, IC50)

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description 1 Introduction to general pharmacology 2 The common routes of drug administration 3 Drug absorption 4 Distribution of drugs in the body 5 Drug elimination 1. Drug metabolism 2. Drug excretion 6 Kinetics of single dose administered drugs 7 Kinetics of repeated dose administered drugs 8 How drugs act 9 Receptor proteins 10 Signal transduction 11 Efficacy, agonists, partial agonists 12 Antagonists, inverse agonists 13 Drug-drug interaction, desensitisation and tachyphylaxis 14 Selectivity of drug effects

Recomended or Required Reading

1. B. Katzung. Basic and Clinical Pharmacology. McGraw-Hill. 12th ed. 2011. 2. Brunton L, Chabner B, Knollman B. Goodman & Gilman's The Pharmacological Basis of Therapeutics. McGraw-Hill. 12th ed. 2011.

Planned Learning Activities and Teaching Methods

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA 1 PRF PERFORMANCE 2 FIN FINAL EXAM 3 FCG FINAL COURSE GRADE PRF * 0.40 + FIN*0.60 4 RST RESIT 5 FCGR FINAL COURSE GRADE (RESIT) PRF * 0.40 + FCGR*0.60

Further Notes About Assessment Methods

A topic of the course outline which is choose with course coordinator must be present as a report

Assessment Criteria

To be succesful in final exam and having a succesfull powerpoint presentation

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

ayse.gelal@deu.edu.tr, Tel: 4123909

Office Hours

To be announced.

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours) Lectures 14 2 28 Preparations before/after weekly lectures 14 9 126 Preparation for final exam 1 16 16 Preparing presentations 1 20 20 Final 1 2 2 TOTAL WORKLOAD (hours) 192

Contribution of Learning Outcomes to Programme Outcomes

PO/LO PO.1 PO.2 PO.3 PO.4 PO.5 PO.6 PO.7 PO.8 LO.1 1 2 4 3 1 1 1 1 LO.2 1 2 4 3 1 1 1 1 LO.3 1 2 4 3 1 1 1 1 LO.4 5 5 4 3 1 1 1 5 LO.5 5 4 4 3 1 1 4 5 LO.6 5 4 4 3 1 1 4 5 LO.7 5 4 4 3 1 4 4 5 LO.8 5 4 4 3 1 4 5 5