COURSE UNIT TITLE

: BIOCHEMICAL BASICS OF CELL BIOLOGY

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
BIO 5038 BIOCHEMICAL BASICS OF CELL BIOLOGY ELECTIVE 3 0 0 4

Offered By

Biochemistry

Level of Course Unit

Second Cycle Programmes (Master's Degree)

Course Coordinator

PROFESSOR DOCTOR GÜLGÜN OKTAY

Offered to

Biochemistry
Nutritional Biochemistry

Course Objective

The course BIO 5007 in the Medical Biochemistry Department addresses the fundamental elements of cellular biochemistry. The BIO 5007 is a prerequisite for this course in which the material presented in BIO 5007 will be continued to address advanced subjects. The syllabus includes; genome structure, gene expression leading to phenotype, cellular organelles, mitochondrial function other than bioenergetics, apoptosis, autophagy, mitosis-miosis, angiogenesis, mechanism of cancer, structure-function relationship in stem cells.

Learning Outcomes of the Course Unit

1   Should have knowledge on genome structure and organization, translocations, DNA nucleotide sequence repair mechanisms.
2   Should have understood mRNA structure, different RNA types, and its role in the formation of cellular phenotype.
3   Should have knowledge on the synthetic role of mitochondria, its transport proteins and its role in cellular biochemistry other that its major role in bioenergetics.
4   Should have adequate knowledge on celuler cytoskeleton, mechanisms of cellular movement, the extracellular matrix and its interrelation with cells.
5   Should have understood mechanisms of cell death, mitosis, and miosis.
6   Should have knowledge on basics mechanisms and pathological processes in vascular biology
7   Should have adequate knowledge on cancer development and stem cell function.
8   Should be able to read, interpret and make a presentation of a given manuscript in the area of the course.

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 Introduction to the cell. Its fundamental structures. Imaging of cells.
2 Detailed understanding of the genome; exons, introns, their function, translocations. Editing the genome. DNA repair mechanisms.
3 Advanced topics in gene expression: mRNA differential splicing, non-coding RNAs. Genotype-phenotype interrelations, cell specific gene expression.
4 Maturation of synthesized proteins and their intracellular traffic.
5 The synthetic role of mitochondria, its transport proteins and its role in cellular biochemistry other that its major role in bioenergetics.
6 Other organelles of the cell; nucleus, lysosome, microsome.
7 Cellar cytoskeleton, cytoskeletal proteins, movement of cells.
8 MID TERM EXAM
9 Extracellular matrix, integrins, othe ECM structures.
10 Vascular biology; angiogenesis, atherosclerosis and their mechanisms.
11 Cell division and its control. Mitosis-meiosis.
12 Cell death; apoptosis and its mechanisms.
13 Other cell death mechanisms (autophagia etc).
14 Uncontrolled cell proliferation: Cancer. Epithelial-mesenchymal transition.
15 Stem cell biology. Mesenchymal stem cells, plupotent stem cells, iPS cells.

Recomended or Required Reading

Textbook(s):
1. Cell Biology. Karp G. 6th Ed. 2010 John Wiley & Sons.

Supplementary Book(s):
1. Mitochondria: A Practical Approach. Darley-Usmar UM, Rickwood D & Wilson MT (eds). 1987, IRL Pres.
2. Apoptosis, Senescence and Cancer. Gewirtz DA, Halt SE, Grant S. (eds) 2nd ed. 2007, Humana Press.

Planned Learning Activities and Teaching Methods

The course is theorethical. It will be presented as lectures. The student is expected to come to class by reading the course materials.
A manuscript will be assigned to each student and he/she will be expected to read, interpret the paper and make a short presentation to the class.

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 MTE MIDTERM EXAM
2 PRJ PROJECT
3 FIN FINAL EXAM
4 FCG FINAL COURSE GRADE MTE * 0.40 +PRJ * 0.10 +FIN* 0.50
5 RST RESIT
6 FCGR FINAL COURSE GRADE (RESIT) MTE * 0.40 +PRJ * 0.10 +RST* 0.50


Further Notes About Assessment Methods

None

Assessment Criteria

Conceptualizing, learning, analysis, comparison, interactive participation.

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

Prof. Dr. Gülgün Oktay
gulgun.oktay@deu.edu.tr
232 412 4404

Office Hours

Wednesday: 10.30-12:15

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 15 3 45
Preparations before/after weekly lectures 2 2 4
Preparation for midterm exam 1 18 18
Preparation for final exam 1 18 18
Preparing presentations 1 15 15
Final 1 3 3
Midterm 1 3 3
TOTAL WORKLOAD (hours) 106

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6
LO.15
LO.25
LO.35
LO.45
LO.55
LO.65
LO.75
LO.855

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

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