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Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS TBG 5033 INTRODUCTION TO CELL ELECTIVE 3 0 0 6

Offered By

The Institute Of Health Sciences

Level of Course Unit

Second Cycle Programmes (Master's Degree)

Course Coordinator

PROFESSOR DOCTOR SULTAN CINGÖZ

Offered to

Clinical Neuroscience (Non-Thesis) Biochemistry Biophysics Microbiology Biomechanics Medical Informatics Department of Biomechanics Scientific Preparatory (Msc) Molecular Medicine Basic Nuclear Medicine Anatomy Histology and Embryology Medical Biology and Genetics Pharmacology Toxicology

Course Objective

Understanding of cell organization and function

Learning Outcomes of the Course Unit

1   Defines the concepts of life 2   Outlines molecular evolution and the evolution of living systems 3   Describes the molecular structure and organization of cells (prokaryote and eukaryote) 4   Explains the processes of genetic information transfer and its control 5   Outlines basic metabolic and energetic processes 6   Defines the concept of signal transduction; lists control mechanisms and pathologies caused by irregularities 7   Recites the mechanisms of cell cycle and cell death, defines the pathologies caused by irregularities 8   Describes cell-cell and cell-environment interactions and can outline the pathologies caused by irregularities 9   Outlines molecular and cellular mechanisms important for life and development of organisms Recognizes basic molecular and cellular mechanisms related to diseases

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description 1 The presentation of Course and the concept of life 2 The importance of water for life; properties, hydrogen bonding, ionization, polarity, hydrophobicity, and hydrophobic interactions, ionization (pH, pK, the equilibrium constant), solubility, osmosis Chemical bonds / Chemical Reactions 3 Biomolecules(I): Carbohydrates and Lipids 4 Biomolecules (II): structure of the proteins yapısı General properties of enzymes and enzymatic reactions (enzymes, coenzymes, cofactors) 5 Biomolecules (III) / DNA and RNA structure Replication 6 Transcriptional and post - transcriptional modifications 7 Cytosol: Composition, function, basic metabolic reactions, osmolality, pH, ionic forces Mitochondria: structure, function, based on biochemical reactions 8 Nucleus: structure, function, chromosomal chromatin, karyoplazma, nuclear membrane and nucleolus Cell division, chromosomal fine structure, cell division in eukaryotes 9 Cytoskeleton, structure and functions of microfilaments, intermediate filaments, microtubules cilia, flagella and steresiliaların 10 Cell membrane structure and function, cell membrane, a thin structure, functional proteins. Article transition: active and passive transport (ion channels, ion transport, factors affecting the membrane potential), phagocytosis, endocytosis, pinocytosis and microvilli 11 Components and functional roles of ECM Cell-cell connection types, structure and functions 12 Overview of intracellular and intercellular signal transduction, signal (signaling) molecules and their receptors, components, structures and functions Receptor types, locations, and intracellular signal transduction pathways (G-protein, Ca, PK, ion channels) Signal transduction with Fosforilasyon-defosforilasyon (Tirozin-Serine/Threonin kinase) 13 Cell cycle, stimulus factors (cytokines, growth factors), and regulation of cell cycle, cyclins Apoptotic and necrotic cell death 14 Causes and development of cancer, oncogenes, tumor suppressor genes, therapeutic approach to cancer treatment

Recomended or Required Reading

References: Molecular Biology of The Cell The cell ( A Moleculer Approach) Fundamentals of Biochemistry-Life at the Molecular Level (D. Voet, J.G. Voet & C. W. Pratt)

Planned Learning Activities and Teaching Methods

The course content will be given a theoretical.

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA 1 MTE MIDTERM EXAM 2 FIN FINAL EXAM 3 FCG FINAL COURSE GRADE MTE * 0.50 + FIN* 0.50 4 RST RESIT 5 FCGR FINAL COURSE GRADE (RESIT) MTE * 0.50 + RST* 0.50

Further Notes About Assessment Methods

None

Assessment Criteria

LO1-LO9:The adequacy of the answers to classical and short-answer questions in Mid-term exam and final exam is assessment criterion

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

Tel: 412 4604 E-Mail: sultan.cingoz@deu.edu.tr

Office Hours

Monday 16:30-17:30

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours) Lectures 14 3 42 Preparation before/after weekly lectures 14 3 42 Preparation for midterm exam 1 6 6 Preparing presentations 8 6 48 Preparation for final exam 1 6 6 Final 1 3 3 Midterm 1 3 3 TOTAL WORKLOAD (hours) 150

Contribution of Learning Outcomes to Programme Outcomes

PO/LO PO.1 PO.2 PO.3 PO.4 PO.5 PO.6 PO.7 PO.8 PO.9 PO.10 PO.11 PO.12 PO.13 PO.14 LO.1 5 5 5 4 5 5 5 4 4 4 4 5 4 5 LO.2 5 5 5 4 5 5 5 4 4 4 4 5 4 5 LO.3 5 5 5 4 5 5 5 4 4 4 4 5 4 5 LO.4 5 5 5 4 5 5 5 4 4 4 4 5 4 5 LO.5 5 5 5 4 5 5 5 4 4 4 4 5 4 5 LO.6 5 5 5 5 5 5 5 4 4 4 4 5 4 5 LO.7 5 5 5 4 5 5 5 4 4 4 4 5 4 5 LO.8 5 5 5 4 5 5 5 4 4 4 4 5 4 5 LO.9 5 5 5 4 5 5 5 4 4 4 4 5 4 5