COURSE UNIT TITLE

: MOLECULAR MECHANISMS OF DISEASE

DEGREE PROGRAMMES

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
BIO 6067 MOLECULAR MECHANISMS OF DISEASE ELECTIVE 2 2 0 9

Offered By

The Institute Of Health Sciences

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

PROFESSOR DOCTOR AYŞE SEMRA KOÇTÜRK

Offered to

Biochemistry
Doctorate Program Rare Diseases

Course Objective

The aim of this course is intensify the knowledge of postgraduate students that they have taken for the duration of training period on biochemistry, microbiology, genetics, and medical biology with molecular metabolism of diseases and metabolic pathways that forms a basis of diseases.
In the application section of the course will provide to learners how to implement the current analytical techniques in hospital laboratory to monitor and diagnosis of diseases. All application demonstrations will put into practice under the guidance of a faculty member.
Knowledge of analyses that unconventional in Dokuz Eylul Hospital Laboratory will support by case report and clinical correlations, which approve by instructor.

Learning Outcomes of the Course Unit

1   Be able to comprehend and understand of the basic metabolism and biochemistry knowledge (Knowledge).
2   Be able to have a basic molecular mechanism (Knowledge)
3   Be able to reach information and data-base related with the application area.(skill)
4   Be able to interpret various problems on various diseases (skill)
5   Learner has skills that present their knowledge on molecular mechanisms of diseases to academic and non-academic communities effectually (know-how)

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 Presentation of the Course Endocrine system diseases and diagnosis in y-the lab. Tyroid, Hypothalamus- hypophis
2 Neoplastic diseases and mechanisms Neoplastic diseae markers
3 Inflectional diseases and molecular mechanisms Diagnosis techniques
4 Molecular mechanisms of blood diseases Hemoglobinopathies, anemia, Thalasemia, G6PDH deficiency
5 Otoimmun diseases. Markers of otoimmun deficiencies.
6 Molecular Mechanism of cardiac diseases Atherosclerosis Myocardial infracts, plasma enzymes and marker proteins. Markers of cardiac obstruction
7 Kidney structure and function Water, Na, K, Ca, Pi, Mg homeostasis and diseases. Renal function tests,
8 GIS s diseases molecular mechanism Liver function tests, plasma proteins Hepatitis, Kolelitiasis,
9 Molecular mechanisms of Carbohydrate metabolism diseases Laboratory analysis of DM, Hypoglysemia,Keton bodies
10 Molecular mechanism of Aging nd degenerative diseases. Laboratory analysis
11 Molecular mechanism of connective tissue diseases. Molecular markers
12 Molecular principles of metabolic diseases. Screening and diagnosis tecniques in lab.
13 Molecular principles of Genetic diseases. Screening and diagnosis tecniques in lab.
14 Diseases of cell mebrane and cellular skeletal system. Mitochondrial diseases, lysosomal diseases, muscular dystrophies.

Recomended or Required Reading

1. Biology of Disease. Eds: Ahmed N., Dawson M., Smith C., Wood E. 2007 by Taylor and &Francis Group, New York.
2. Textbook of Clinical Chemistry and Molecular Diagnostics. Eds: Burtis CA, Ashwood ER, Bruns DE, 4th edition, 2006, Elsevier Saunders, St Louis.
3. Textbook of Biochemistry with Clinical Correlations. Sixth edition. 2005, Ed. Thomas M. Devlin. John-Wiley& Sons Inc. Publication, USA
4. Human Molecular genetics 3. Tom Strachan and Andrew P. Read. Garland Science, UK 2004
5. Thompson and Thompson genetics in Medicine. Nussbaum RL, McInnes RR, Huntington FW. (Çeviri kitap). Güneş Kitabevi. Ankara,2005
6. Alonso AC, Li B, Grundke-Iqbal I, Iqbal K. Mechanism of tau-induced neurodegeneration in Alzheimer disease and related tauopathies.Curr Alzheimer Res. 2008 Aug;5(4):375-84. Review.

Planned Learning Activities and Teaching Methods

Comprehension of theoretical knowledge on molecular mechanisms of diseases will provide by lectures and learning of analytical technics will provide by application sections in hospital laboratory.

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 ASG ASSIGNMENT
2 PAR PARTICIPATION
3 FIN FINAL EXAM
4 FCG FINAL COURSE GRADE ASG * 0.30 +PAR * 0.30 +FIN* 0.40
5 RST RESIT
6 FCGR FINAL COURSE GRADE (RESIT) ASG * 0.30 +PAR * 0.30 +RST* 0.40


Further Notes About Assessment Methods

None

Assessment Criteria

1. Learner theoretical knowledge on molecular mechanism of diseases will evaluated with assignments, laboratory works and final exam (PO1,PO2)
2. Learner skills on to reach information and data-base related with the application area, planning of experiment will evaluate via assignments (PO6,PO7)
3. Learner knowledge on basic laboratory technics that will use monitoring and diagnosis of disease will evaluate via all application sessions and an assignment
(PO10)

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

semra.kocturk@deu.edu.tr, 4124407

Office Hours

on Tuesday at: 13.30-16.30

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 15 2 30
Tutorials 15 2 30
Preparations before/after weekly lectures 15 5 75
Preparation for final exam 1 48 48
Preparing assignments 3 10 30
Preparing presentations 3 3 9
Final 1 3 3
TOTAL WORKLOAD (hours) 225

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10PO.11PO.12PO.13
LO.155
LO.255
LO.35
LO.45
LO.55

CONTACT INFORMATION
Dokuz Eylül Üniversitesi Cumhuriyet Bulvarı No: 144 35210 Alsancak / İZMİR
Phone: +90(232) 412 12 12 - Fax: +90 (232) 464 81 35

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