COURSE UNIT TITLE

: FUNDAMENTAL PRINCEPLES OF GLYCOBIOLOGY

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
KIM 5108 FUNDAMENTAL PRINCEPLES OF GLYCOBIOLOGY ELECTIVE 3 0 0 7

Offered By

Graduate School of Natural and Applied Sciences

Level of Course Unit

Second Cycle Programmes (Master's Degree)

Course Coordinator

PROFESSOR DOCTOR MUSTAFA YAVUZ ERGÜN

Offered to

M.Sc.Biochemistry
Chemistry
Chemistry
Ph.D in Biochemistry

Course Objective

The chemistry and metabolism of carbohydrates were prominent matters of interest in the first part of the 20th century. The biological roles of carbohydrates are particularly important in the assembly of complex multicellular organs and organisms, which requires interactions between cells and the surrounding matrix. The course aims the structure, metabolism and biological roles of carbohydrates and their derivates as well as the diseases about glycobiology.

Learning Outcomes of the Course Unit

1   Realize carbohydrates and their classification and metabolism,
2   Comprehend the structural basis of glycans and protein-glycan interactions,
3   Understand cellular organization of glycosylation and its precursors,
4   Realize the mechanism of glycan-processing enzymes and glycosyltransferases,
5   Comprehend the role of glycans in genetic disorders and disease.

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 Overview of Glycobiology
2 Structure, Terminology and Glycan Diversity of Carbohydrates
3 Carbohydrate Metabolism
4 Protein-Glycan Interactions
5 Biological Roles of Glycans
6 Glycosphingolipids and Their Binding
7 Proteoglycans and Glycosamineglycans
8 Midterm
9 Glycosylation in Nucleus and Cytoplasm
10 Basic Structures of Sialic Acid and Different Type of Glycans
11 Glycosyltransferases
12 Lectins, Selectins and Galectins
13 Role of Glycans in Genetic Disorders and Diseases
14 Presentations

Recomended or Required Reading

Textbook(s): Varki, A., Cummings, R. D., Esko, J. D., Freeze, H. H., Stanley, P., Bertozzi, C. R., Hart, G. E., Etzler, M. E., Essentials of Glycobiology, Cold Spring Harbor Laboratory Press, USA, 2009.
Supplementary Book(s): Fukuda, M., Hindsgaul, O., Molecular and Cellular Glycobiology, Oxford University Press, USA, 2000.

Planned Learning Activities and Teaching Methods

1. Presentation
2. Interactive narrative
3. Question-answer technique
4. Home work

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 MTE MIDTERM EXAM
2 ASG ASSIGNMENT
3 PAR PARTICIPATION
4 FIN FINAL EXAM
5 FCG FINAL COURSE GRADE
6 RST RESIT
7 FCGR FINAL COURSE GRADE (RESIT)


Further Notes About Assessment Methods

None

Assessment Criteria

Meaningful learning of the basic concepts given in presentations, association of concepts with each other, establishing the cause-result relationships and making comments by using the information available for problems and evaluating idea generation are carried out with mid-term and final exams, active participation to the lecture, homework.

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

hulya.kayali@deu.edu.tr

Office Hours

Wednesday 13.30-15.30

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 13 3 39
Preparations before/after weekly lectures 13 3 39
Preparation for midterm exam 1 10 10
Preparation for final exam 1 20 20
Preparing assignments 2 15 30
Preparing presentations 2 15 30
Final 1 2 2
Midterm 1 2 2
TOTAL WORKLOAD (hours) 172

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10PO.11
LO.15555555
LO.255555555
LO.35555555
LO.45555555
LO.555555555