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Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS BST 5016 INTRODUCTION TO MEDICINAL CHEMISTRY ELECTIVE 3 0 0 9

Offered By

Biomedicine and Health Technologies

Level of Course Unit

Second Cycle Programmes (Master's Degree)

Course Coordinator

ASSOCIATE PROFESSOR MUHAMMED ÜÇÜNCÜ

Offered to

Biomedicine and Health Technologies

Course Objective

The purpose of this lecture is to provide a comprehensive understanding of the key concepts in medicinal chemistry.

Learning Outcomes of the Course Unit

1   Understanding the fundamental principles and scope of medicinal chemistry, the processes of drug discovery and development, and the importance of physicochemical properties. 2   Describing how drugs interact with biological targets (such as receptors, enzymes, and nucleic acids) and explaining their mechanisms of action. 3   Interpreting structure activity relationships (SAR) and applying strategies including optimization and prodrug development in drug design. 4   Comparing the chemical and biological principles in the design of antibacterial, antiviral, and anticancer agents. 5   Learning about current trends in modern drug design and major challenges such as resistance, selectivity, and emerging technologies.

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description 1 Introduction to Medicinal Chemistry Ilaç Kimyasına Giriş 2 Physicochemical Properties of Drugs Ilaçların Fizikokimyasal Özellikleri 3 Drug Receptor Interactions Ilaç Reseptör Etkileşimleri 4 Drug targets Ilaç Hedefleri 5 Mechanisms of Action Etki Mekanizmaları 6 Drug discovery: Structure activity relationship (SAR) Ilaç Keşfi: Yapı Aktivite Ilişkisi (SAR) 7 Strategies in drug design Ilaç Tasarımında Stratejiler 8 Mid-term Ara Sınav 9 Optimizing to access to target Hedefe Yönelik Optimizasyon Yaklaşımları 10 Prodrugs Ön Ilaçlar 11 Antibacterial agents Antibakteriyel Ajanlar 12 Antiviral agents Antiviral Ajanlar 13 Anticancer agents Antikanser Ajanlar 14 Current trends in drug design Modern Ilaç Tasarımındaki Güncel Eğilimler 15 Challenges in drug design Ilaç Tasarımındaki Zorluklar 16 Final Exam Final Sınavı

Recomended or Required Reading

Graham L. Patrick An Introduction to Medicinal Chemistry 5th edition. Gareth Thomas Fundamentals of Medicinal Chemistry 1st edition.

Planned Learning Activities and Teaching Methods

Presentations, literature review / discussion / presentation, problem solving

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA 1 ASG ASSIGNMENT 2 MTE MIDTERM EXAM 3 FIN FINAL EXAM 4 FCG FINAL COURSE GRADE ASG * 0.30 + MTE * 0.30 + FIN * 0.40 5 RST RESIT 6 FCGR FINAL COURSE GRADE (RESIT) ASG * 0.30 + MTE * 0.30 + RST * 0.40

Further Notes About Assessment Methods

None

Assessment Criteria

The level of achievement of learning outcomes will be assessed based on the answers given to the exam questions, as well as the performance in assignments and presentations.

Language of Instruction

English

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

muhammed.ucuncu@deu.edu.tr

Office Hours

Fridays during 14.00-15.00

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours) Lectures 14 3 42 Preparations before/after weekly lectures 14 5 70 Preparation for midterm exam 1 15 15 Preparation for final exam 1 20 20 Preparing assignments 1 25 25 Preparing presentations 1 30 30 Final 1 10 10 Midterm 1 5 5 TOTAL WORKLOAD (hours) 217

Contribution of Learning Outcomes to Programme Outcomes

PO/LO PO.1 PO.2 PO.3 PO.4 PO.5 PO.6 PO.7 PO.8 LO.1 4 3 4 4 3 2 2 3 LO.2 3 4 3 3 4 3 2 3 LO.3 4 3 3 3 4 3 2 3 LO.4 4 4 3 3 3 3 2 3 LO.5 3 3 3 3 4 3 3 4