COURSE UNIT TITLE

: NON-CODING RNA S IN CANCER RESEARCH

Description of Individual Course Units

Course Unit Code Course Unit Title Type Of Course D U L ECTS
TRO 6027 NON-CODING RNA S IN CANCER RESEARCH ELECTIVE 3 0 0 6

Offered By

Translational Oncology

Level of Course Unit

Third Cycle Programmes (Doctorate Degree)

Course Coordinator

ASSOCIATE PROFESSOR MELTEM ALPER

Offered to

Translational Oncology

Course Objective

The aim of the course to teach the structure and types of the non-coding RNA s and also effects and mechanisms of the non-coding RNA s in gene regulation. In addition, to introduce the effect of the non-coding RNA s in cancer development and progression and to explain their importance in cancer diagnosis and treatment

Learning Outcomes of the Course Unit

1   Be able to learn about the RNA content of the genome.
2   Be able to learn about the types and properties of non-coding RNAs.
3   Be able to learn about the effects of non-coding RNAs on gene regulation.
4   Be able to learn about the role of non-coding RNAs in cancer formation and progression.
5   Be able to learn about the importance of non-coding RNAs in cancer diagnosis and treatment.

Mode of Delivery

Face -to- Face

Prerequisites and Co-requisites

None

Recomended Optional Programme Components

None

Course Contents

Week Subject Description
1 RNA content of the genome, Classification of non-coding RNAs Hallmarks of cancer and non-coding RNAs-2
2 Properties of long non-coding RNAs (long non-coding RNAs) and their effects on gene regulation-1 The importance of non-coding RNAs in cancer diagnosis and treatment-1
3 Properties of long non-coding RNAs (long non-coding RNAs) and their effects on gene regulation-2 The importance of non-coding RNAs in cancer diagnosis and treatment-2
4 Properties of small non-coding RNAs (long non-coding RNAs) and their effects on gene regulation-1 The importance of non-coding RNAs in cancer diagnosis and treatment-2
5 Properties of small non-coding RNAs (long non-coding RNAs) and their effects on gene regulation-2 Bioinformatics Analysis tools used to study the function and interactions of non-coding RNAs
6 Effects of Long Non-Coding RNAs on Cancer development and progression-1 Examination of current literature
7 Effects of Long Non-Coding RNAs on Cancer development and progression-2
8 Effects of small non-coding RNAs on cancer development and progression-1
9 Effects of small non-coding RNAs on cancer development and progression-2
10 Hallmarks of cancer and non-coding RNAs-1

Recomended or Required Reading

Ders Için Önerilen Kaynaklar:
1-Methods in Molecular Biology, Long Non-coding RNA s in Cancer. Editor, Alfons Navarro Humana Press, 2021.
2-Advances in Experimental Medicine and Biology.The Long and Short Non-Coding RNA s in Cancer Biology, Editor Erwei Song ,Springer, 2016.
3-Uppaluri KR, Challa HJ, Gaur A, Jain R, Krishna Vardhani K, Geddam A, Natya K, Aswini K, Palasamudram K, K SM. Unlocking the potential of non-coding RNAs in cancer research and therapy. Transl Oncol. 2023 Sep;35:101730. doi: 10.1016/j.tranon.2023.101730. Epub 2023 Jul 3. PMID: 37406550; PMCID: PMC10366642.
4-Le P, Romano G, Nana-Sinkam P, Acunzo M. Non-Coding RNAs in Cancer Diagnosis and Therapy: Focus on Lung Cancer. Cancers (Basel). 2021 Mar 18;13(6):1372. doi: 10.3390/cancers13061372. PMID: 33803619; PMCID: PMC8003033.

Planned Learning Activities and Teaching Methods

Theoretical lectures, reinforcement and discussion of the subjects with in-class activities (presentations and assignments)

Assessment Methods

SORTING NUMBER SHORT CODE LONG CODE FORMULA
1 PRF PERFORMANCE
2 FIN FINAL EXAM
3 FCG FINAL COURSE GRADE PRF * 0.40 + FIN*0.60
4 RST RESIT
5 FCGR FINAL COURSE GRADE (RESIT) PRF * 0.40 + FCGR*0.60


Further Notes About Assessment Methods

None

Assessment Criteria

Assessment with homework and PRESENTATION (Learning outcome 1,2 and 3)
Assessment with the exam (Learning outcome1,2,3 4,5 )

Language of Instruction

Turkish

Course Policies and Rules

To be announced.

Contact Details for the Lecturer(s)

To be announced.

Office Hours

Thursday 14.00-15.00

Work Placement(s)

None

Workload Calculation

Activities Number Time (hours) Total Work Load (hours)
Lectures 15 3 45
Preparations before/after weekly lectures 15 2 30
Preparation for final exam 5 5 25
Preparing assignments 5 3 15
Preparing presentations 5 7 35
Final 1 2 2
TOTAL WORKLOAD (hours) 152

Contribution of Learning Outcomes to Programme Outcomes

PO/LOPO.1PO.2PO.3PO.4PO.5PO.6PO.7PO.8PO.9PO.10PO.11PO.12
LO.1555555
LO.255555
LO.355555
LO.455555
LO.555555