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Associate Professor CAN KÜÇÜK FACULTY OF MEDICINE BASIC MEDICAL SCIENCES DEPARTMENT OF MEDICAL BIOLOGY

 can.kucuk@deu.edu.tr
 +90 232 - -

Education/Academic Info
Undergraduate Degree	Middle East Technical University Fen Edebiyat Fakültesi Moleküler Biyoloji ve Genetik	2005
PhD (Doctorate)	The University of Nebraska , Kanser Biyolojisi ve Onkoloji	2012
Assistant Professor	Dokuz Eylül University Tıp Fakültesi	2015
Associate Professor	Dokuz Eylül University Tıp Fakültesi Tıbbi Biyoloji	2018

NO	NAME	YEAR
1	Whole exome sequencing reveals genetic variants in low-risk and high-risk neuroblastoma...	2023
2	Genetic and epigenetic analyses reveal transcriptional silencing of SOX7 due to deletion in a multip...	2023
3	New insights into epigenetic regulation of resistance to PD-1/PD-L1 blockade cancer immunotherapy: m...	2022
4	Whole Transcriptome Sequencing Reveals Cancer-Related, Prognostically Significant Transcripts and Tu...	2022
5	Plasma Concentrations and Cancer-Associated Mutations in Cell-Free Circulating DNA of Treatment-Naiv...	2022
6	In Silico Methods for the Identification of Diagnostic and Favorable Prognostic Markers in Acute Mye...	2021
7	PRDM1 decreases sensitivity of human NK cells to IL2-induced cell expansion by directly repressing C...	2021
8	A prognostic model for melanoma patients on the basis of immune-related lncRNAs...	2021
9	Indolent T-Cell Lymphoproliferative Disease of the GI Tract: Insights for Better Diagnosis, Prognosi...	2020
10	Genetic alterations in B cell lymphoma subtypes as potential biomarkers for noninvasive diagnosis, p...	2020
11	Genetic susceptibility to natural killer T-cell lymphoma...	2020
12	Epigenetic aberrations in natural killer/T-cell lymphoma: diagnostic, prognostic and therapeutic imp...	2020
13	Systematic analysis of the frequently amplified 2p15-p16.1 locus reveals PAPOLG as a potential proto...	2019
14	Primary cardiac diffuse large B-cell lymphoma with concurrent high MYC and BCL2 expression in an imm...	2017
15	Whole transcriptome analysis reveals dysregulated oncogenic lncRNAs in natural killer/T-cell lymphom...	2017
16	The relationship of REL proto-oncogene to pathobiology and chemoresistance in follicular and transfo...	2017
17	Clinicopathologic Characterization of Aggressive Natural Killer Cell Leukemia Involving Different Ti...	2016
18	Diagnostic and Biological Significance of KIR Expression Profile Determined by RNA-Seq in Natural Ki...	2016
19	Generation of a genetically engineered aggressive NK-cell leukemia cell line with stable IL2 express...	2015
20	Lack of Evidence that HACE1 Is Not a Tumor Suppressor Gene in NKTCL: To the Editor-in-Chief...	2015
21	Global promoter methylation analysis reveals novel candidate tumor suppressor genes in natural kille...	2015
22	Activating mutations of STAT5B and STAT3 in lymphomas derived from ??-T or NK cells...	2015
23	Genome-wide copy number analyses reveal genomic abnormalities involved in transformation of follicul...	2014
24	Indolent T-cell lymphoproliferative disease of the gastrointestinal tract...	2013
25	MicroRNA expression profiling identifies molecular signatures associated with anaplastic large cell ...	2013
26	HACE1 is a Tumor Suppressor Gene Candidate in Natural Killer Cell Neoplasms...	2013
27	IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma...	2012
28	PRDM1 is a Tumor Suppressor Gene in Natural Killer Cell Malignancies...	2011
29	NK-cell lymphoma shares strikingly similar molecular features with a distinct subset of T-cell lymph...	2011
30	Synaptic Development of the Mouse Dorsal Geniculate Nucleus...	2010
31	Molecular signatures to improve diagnosis in peripheral T-cell lymphoma and prognostication in angio...	2010
32	Genomic analyses reveal global functional alterations that promote tumor growth and novel tumor supp...	2009
33	Clinical implication of genome-wide profiling in diffuse large B-cell lymphoma and other subtypes of...	2007

NO	NAME	DATE
1	PRDM1 Promotes Primary Human Circulating CD56dim NK-Cell Differentiation...	09/12/2023 -
2	Genetik ve epigenetik olarak sessizleşen SOX7'nin multipl miyelomdaki tümör baskılayıcı gen...	02/11/2023 -
3	SOX7 is a candidate tumor suppressor gene in multiple myeloma...	17/08/2023 - 19/08/2023
4	SOX7 tümör baskılayıcı adayı iki kez nükseden multipl miyelom olgusu tümörlerinde genetik o...	04/11/2021 - 07/11/2021
5	Ultra-Deep Targeted Sequencing Reveals Cancer-Associated, Prognostically Significant Mutations in Ci...	05/12/2020 - 08/12/2020
6	CD25 (IL2RA) Is a Direct Transcriptional Target of PRDM1 in Activated Human Natural Killer Cells...	01/12/2018 - 04/12/2018
7	Foliküler lenfoma dolaşımsal serbest DNA'sının invazif olmayan tanı amaçlı genomik profil an...	01/11/2018 - 03/11/2018
8	Doğal öldürücü/T hücre lenfomalarında tüm transkriptom analizi sonucu disregüle olan kanser...	26/10/2017 - 29/10/2017
9	THE ROLE OF REL PROTO ONCOGENE IN FOLLICULAR LYMPHOMA DEVELOPMENT...	27/10/2016 - 20/10/2016
10	Lenfoid Kanser Genomiği...	27/06/2016 -
11	Functional genomics of NK and gamma-delta T cell lymphomas: therapeutic and diagnostic implications...	17/02/2016 -
12	STAT5B ve STAT3 sürücü mutasyonları gamma delta T ve doğal öldürücü hücrelerden türeyen p...	27/10/2015 - 30/10/2015
13	RNA-Seq analysis reveals KIR2DL4 expression as a clonal diagnostic marker and potential therapeutic ...	17/10/2015 -
14	Frequent Activating Mutations Of JAK-STAT Pathway Genes In Natural Killer Cell Lymphomas...	10/12/2013 -
15	Global Methylation Analysis Reveals Novel Candidate Tumor Suppressor Genes In Natural Killer Cell Ly...	07/12/2013 -
16	Genetic Abnormalities in Follicular Lymphoma and Transformed Follicular Lymphoma...	08/12/2012 - 11/12/2012
17	NK-Cell Lymphoma Shares Strikingly Similar Molecular Features with a Distinct Set of gamma-delta T-C...	05/12/2009 - 08/12/2009
18	Genomic Analyses Reveal Global Functional Alterations That Promote Tumor Growth and Novel Tumor Supp...	08/12/2008 -
19	Molecular Signatures to Improve Diagnosis, Prognostication and Identification of Oncogenic Pathways ...	05/12/2008 - 08/12/2008

NO	CHAPTER TITLE	YEAR
1	Genomik ve UygulamalarıMoleküler Biyoloji ve Genetik - Sağlık Alanında ve Biyoteknolojide İleri Uygulamalar...	2023
2	Lenfoma Genetiği (HL, NHL, B-cell lenfoma, KLL) HematoLog...	2019

NO	NAME	DATE
1	Pediatrik Burkitt Lenfoma Hastalarında Dolaşımsal Serbest ve Ekzozomal MikroRNA İfade Seviyelerinin İnvazif Olmayan Tanı Biyobelirteci Olma Potansiyellerinin İncelenmesi....	11/2018 - 5/2022
2	Türkiyede akraba evliliklerine baglı nörogenetik hastalık yükünün arastırılmasında yeni genomik yaklasımlar...	12/2016 - 6/2020

NO	NAME	DATE
1	Genç Bilim İnsanı ödülü (BAGEP)...	2015
2	Uluslarararası Genç Bilim İnsanı Ödülü...	2018
3	Amerika Hematoloji Derneği (ASH) Takviye Ödülü...	2021
4	Genç Araştırmacı Birincilik Ödülü...	2017
5	TÜBA-Üstün Başarılı Genç Bilim İnsanlarını Ödüllendirme Programı (TÜBA-GEBİP)...	2017
6	46.Ulusal Hematoloji Kongresi Ulusal Kongre Bildiri Ödülü...	2020
7	Onkolojide İz Bırakanlar Makale Ödülü...	2019
8	Amerika Hematoloji Derneği Çalışma Özeti Başarı Ödülü...	2013
9	ASH Uluslararası Sosyal Destek İnisiyatifi...	2023
10	Amerika Hematoloji Derneği Küresel Araştırma Ödülü...	2018

NO	NAME	YEAR
1	Türkiye Bilimsel ve Teknolojik Araştırma Kurumu	2002
2	Avrupa Hematoloji Topluluğu (EHA)	2018