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  • Education/Academic Info
    Undergraduate Degree  Gazi University Eczacılık Fakültesi  1974
    Master's Degree  Paris XI Üniversitesi Eczacılık Fakültesi Biyokimya Anabilim Dalı  1979
    PhD (Doctorate)  Universite de Paris-Sud Farmasötik Bilimler  1986
    Associate Professor  Turkish Inter-Universities Board Moleküler Biyoloji  1990
    Full Professor  İ. D. Bilkent University Fen Fakültesi Moleküler Biyoloji  1995
  • NO NAME YEAR
    1  Development of a novel zebrafish xenograft model in ache mutants using liver cancer cell lines...  2018
    2  A novel chromonyl thiohydantoin with anti-proliferative action on primary hepatocellular carcinoma c...  2017
    3  Thiazolidinedione or Rhodanine: A Study on Synthesis and Anticancer Activity Comparison of Novel Thi...  2017
    4  Molecular Pathogenesis of Liver Cancer....  2017
    5  Phenacyl group containing amide derivative of dehydroabietylamine exhibiting enhanced cytotoxic acti...  2017
    6  Synergistic activity of vorinostat combined with gefitinib but not with sorafenib in mutant KRAS hum...  2016
    7  Synthesis and bio-molecular study of (+)-N-Acetyl-?-amino acid dehydroabietylamine derivative for th...  2016
    8  Liver cancer cells are sensitive to Lanatoside C induced cell death independent of their PTEN status...  2016
    9  Role of Fanconi Anemia/BRCA Pathway Genes in Hepatocellular Carcinoma Chemoresistance...  2016
    10  Molecular Biology of Liver Cancer....  2015
    11  Common telomerase reverse transcriptase promoter mutations in hepatocellular carcinomas from differe...  2015
    12  Comparative evaluation of in vitro cytotoxic effects among parent abietyl alcohol and novel fatty ac...  2014
    13  Synthesis and characterization of amino acid conjugates of oleanolic acid and their in vitro cytotox...  2014
    14  Genetics and epigenetics of liver cancer...  2013
    15  Genetics and epigenetics of liver cancer...  2013
    16  Genome-Wide Transcriptional Reorganization Associated with Senescence-to-Immortality Switch during H...  2013
    17  Genome-Wide Transcriptional Reorganization Associated with Senescence-to-Immortality Switch during H...  2013
    18  Novel anti-HER2 monoclonal antibodies: synergy and antagonism with tumor necrosis factor-alpha....  2012
    19  Inhibition of Akt signaling in hepatoma cells induces apoptotic cell death independent of Akt activa...  2011
    20  Dose- and time-dependent expression patterns of zebrafish orthologs of selected E2F target genes in ...  2011
    21  Dose- and Time-dependent Expression Patterns of Zebrafish Orthologs of Selected E2F Target Genes in ...  2011
    22  Systems medicine and integrated care to combat chronic noncommunicable diseases...  2011
    23  Induction of ROS, p53, p21 in DEHP- and MEHP-exposed LNCaP cells-protection by selenium compounds...  2011
    24  Inhibition of Akt signaling in hepatoma cells induces apoptotic cell death independent of Akt activa...  2011
    25  Aflatoxin genotoxicity is associated with a defective DNA damage response bypassing p53 activation...  2011
    26  Mdm2 Snp309 G allele displays high frequency and inverse correlation with somatic P53 mutations in ...  2010
    27  Analysis of the Wnt/B-catenin/TCF4 pathway using SAGE, genome-wide microarray and promoter analysis:...  2010
    28  Evaluation of cytotoxicity and oxidative DNA damaging effects of di(2-ethylhexyl)-phthalate (DEHP) a...  2010
    29  Transforming growth factor-beta induces senescence in hepatocellular carcinoma cells and inhibits tu...  2010
    30  Transforming growth factor-beta induces senescence in hepatocellular carcinoma cells and inhibits tu...  2010
    31  The ability to generate senescent progeny as a mechanism underlying breast cancer cell heterogeneity...  2010
    32  Senescence and immortality in hepatocellular carcinoma....  2009
    33  Senescence and immortality in hepatocellular carcinoma...  2009
    34  Canonical Wnt signaling is antagonized by noncanonical Wnt5a in hepatocellular carcinoma cells...  2009
    35  Canonical Wnt signaling is antagonized by noncanonical Wnt5a in hepatocellular carcinoma cells...  2009
    36  Nuclear exclusion of p33ING1b tumor suppressor protein: explored in HCC cells using a new highly spe...  2009
    37  Homozygosity at variant MLH1 can lead to secondary mutation in NF1, Neurofibromatosis Type I and Ear...  2008
    38  Immunization with UV-induced apoptotic cells generates monoclonal antibodies against proteins differ...  2007
    39  Redundant expression of canonical Wnt ligands in human breast cancer cell lines....  2006
    40  Reprogramming of replicative senescence in hepatocellular carcinoma-derived cells...  2006
    41  Reprogramming of replicative senescence in hepatocellular carcinoma-derived cells...  2006
    42  Lithium-mediated downregulation of PKB/Akt and cyclin E with growth inhibition in hepatocellular car...  2005
    43  A new set of monoclonal antibodies directed to proline-rich and central regions of p53...  2004
    44  Expression of TAP73 and DeltaNP73 in malignant gliomas....  2004
    45  Acquired tolerance of hepatocellular carcinoma cells to selenium deficiency: a selective survival me...  2003
    46  Identification of genes induced by BRCA1 in breast cancer cells....  2002
    47  Molecular characterization of a full genome Turkish Hepatitis C virus 1b isolate (HCV-TR1): a predom...  2002
    48  p53 mutation as a source of aberrant b-catenin accumulatıon in cancer cells....  2002
    49  PATIKA: An integrated visula environment for collaborative construction and analysis of cellular pat...  2002
    50  NAPO as a novel apoptosis marker...  2001
    51  Acquired expression of transcriptionaly active p73 in hepatocellular carcinoma....  2001
    52  P53 codon 249 mutation in hepatocellular carcinomas from Nigeria....  2001
    53  Germ line BRCA1 and BRCA2 gene mutations in Turkish breast cancer patients....  2000
    54  p53 but not p16INK4a induces growth arrest in retinoblastoma-deficient hepatocellular carcinoma ce...  2000
    55  The exon 13 duplication in the BRCA1 gene is a founder mutation present in geographically diverse po...  2000
    56  Differential p21 expression after ionizing and UVC irradiation in EBV-transformed lymphoblastoid c...  2000
    57  p53 mutations as fingerprints of environmental carcinogens....  2000
    58  A highly sensitive and specific enzyme-linked immunosorbent assay of antibodies to hepatitis C virus...  2000
    59  Smad2 and Smad4 Gene Mutations in Hepatocellular Carcinoma...  1999
    60  Genetic aspects of hepatocarcinogenesis...  1999
    61  Human MLH1 deficiency predisposes to hepatological malignancy and neurofibromatosis type 1...  1999
    62  Thymidine dinucleotides induce S phase cell cycle arrest in addition to increased melanogenesis in h...  1998
    63  Prognostic value of p53 gene mutations in a large series of node-negative breast cancer patients...  1998
    64  Cell Cycle gene regulation in reversibly differentiated new human hepatoma cell lines...  1998
    65  Germline hMSH2 and hMLH1 gene mutations in complete HNPCC families....  1997
    66  TP53 in Hepatocellular Carcinoma...  1997
    67  p21WAF1/CIP1 response to genotoxic agents in wild-type TP53-expressing breast primary tumours...  1997
    68  Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular res...  1996
    69  Genomic instability in colorectal cancers in Turkey....  1996
    70  Alteration of p53 damage response by tamoxifen treatment....  1996
    71  Evidence for an hereditary p53 syndrome in cancer-prone families....  1996
    72  Annexin II up-regulates cellular levels of p11 protein by a post-translational mechanism....  1996
    73  p53 mutations in nonmalignant human liver: fingerprints of aflatoxins?...  1995
    74  Somatic mutations of von Hippel-Lindau tumor suppressor gene in european kidney cancers...  1995
    75  Hepatocarcinoma-specific mutant p53-249ser induces mitotic activity but has no effect on TGF-beta-me...  1995
    76  Genomic stability and wild-type p53 function of lymphoblastoid cells with germ-line p53 mutation....  1995
    77  Ras, p53 and HPV status in benign and malignant prostate tumors...  1995
    78  p53-mediated cellular response to DNA damage in cells with replicative Hepatitis B Virus...  1995
    79  La p53 dans tous ses états...  1994
    80  p53, UV light and carcinogenesis...  1994
    81  Two germ-line mutations affecting the same nucleotide at codon 257 of p53 gene:...  1994
    82  Two germ-line mutations affecting the same nucleotide at codon 257 of p53 gene: a rare site for muta...  1994
    83  Genetic heterogeneity of hepatocellular carcinoma....  1994
    84  Retinoblastoma and p53 tumor suppressor genes in human hepatoma cell lines...  1993
    85  The effects of cytokines on human chorionic gonatropin (hCG) production by a trophoblast cell line...  1993
    86  p53 as a growth suppressor gene in HBV-related hepatocarcinoma cells....  1993
    87  Oncogenes et genes suppresseur de cancer...  1992
    88  p53 as a potential target for cancer therapy....  1992
    89  The major histocompatibility complex class I antigen-binding protein p88 is the product of calnexin ...  1992
    90  Selective targeting of p53 mutational hotspots in human cancers by etiologically defined carcinogens...  1991
    91  Human chorionic gonadotropin, its free subunits and gestational trophoblastic disease...  1991
    92  p53 mutation in hepatocellular carcinoma after aflatoxin exposure...  1991
    93  Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa....  1991
    94  Interet clinique des dosages ultrasensibles et totalement specifiques de l?hormone chorionique gonad...  1990
    95  First trimester maternal serum alpha-fetoprotein and human chorionic gonadotropin screening for chro...  1990
    96  Enhanced expression of an exocrine pancreatic protein in Alzheimer's disease and the developing huma...  1990
    97  Expression of human a-actinin during hepatocyte proliferation and in hepatocellular carcinoma...  1990
    98  Enhanced expression of the protein-kinase substrate p36 in human hepatocellular carcinoma...  1990
    99  Abnormal maternal serum levels of human chorionic gonadotropin free subunits in trisomy 18....  1990
    100  Abnormal structure and expression of p53 gene in human hepatocellular carcinoma....  1990
    101  Characterization of a malignant phenotype-associated cell surface glycoprotein common to various hum...  1989
    102  Identification and characterization of a Mr. 50,000 adrenal protein in human hepatocellular carcinom...  1989
    103  hCG and free subunits serum levels in patients with partial and complete hydatidiform moles...  1989
    104  In vivo expression of two novel tumor associated antigens and their use in immunolocalization of hum...  1989
    105  Radioimmunolocalization of hepatic and pulmonary metastasis of colon adenocarcinoma...  1989
    106  . Elevated levels of an exocrine pancreatic secretory protein in Alzheimer's disease brain...  1989
    107  In vivo localization of colon adenocarcinoma by monoclonal antibody binding to a highly expressed ce...  1988
    108  Physiological studies of human chorionic gonadotropin and free subunits in the amniotic fluid compar...  1988
    109  Differential production of hCG and free subunits in gestational trophoblastic disease...  1988
    110  Cell surface changes associated with transformation of human hepatocytes to the malignant phenotype...  1988
    111  Synthetic peptides and monoclonal antibodies of predetermined specificity in the study of human chor...  1987
    112  Physiologic studies of human chorionic gonadotropin (hCG), ahCG and bhCG as measured by specific mon...  1987
    113  Ectopic b-human chorionic gonadotropin production by a human hepatoma cell line (FOCUS): isolation a...  1987
    114  Changes in methionine metabolism induced by D-galactosamine in isolated rat hepatocytes...  1986
    115  Sensitive and specific assays for human chorionic gonadotropin based on anti-peptide and anti-hCG mo...  1986
    116  Identification of epitopes associated with hCG and beta-hCG carboxyl terminus by monoclonal antibodi...  1985
    117  Methionine metabolism and ultra structural changes with D-galactosamine in isolated rat hepatocytes....  1984
    118  A monoclonal antibody against a synthetic peptide is specific for the free native human chorionic go...  1984
    119  Anticorps monoclonaux dirigés contre la sous-unité béta-hCG et contre un peptide synthetique anal...  1984
    120  A simple radioactivity assay for measurement of methionine adenosyltransferase activity by aqueous c...  1983
  • NO NAME DATE
    1  Hepatoselüler karsinomda AXL'ın rolü... 14/11/2019 - 17/11/2019
    2  Hepatoselüler karsinomda TGF-ß yanıtının hücresel mekanizmalarının araştırılması... 14/11/2019 - 17/11/2019
    3  Turkish Journal of Biochemistry... 14/11/2019 - 17/11/2019
    4  Biyofarmasötik Teknoloji ile Üretilen Terapötik Monoklonal Antikorların, Kromatografik ve Elektr... 29/10/2019 - 31/10/2019
    5  AXL as a Potential Target in Liver Cancer... 05/09/2018 - 08/09/2018
    6  Investigation of the Cellular Mechanisms of TGF-beta-induced Senescence-Resistance in Hepatocellular... 05/09/2018 - 08/09/2018
    7  TAp73 beta induces tumor inhibition in hepatocellular carcinoma... 03/09/2016 - 08/09/2016
    8  Mechanism of TAp73 Beta-MDM2 autoregulation... 03/09/2016 - 08/09/2016
    9  Synthesis and HDACi Activity of Novel Thiazole Substituted Benzamide Compounds... 15/02/2016 - 17/02/2016
    10  Differentiation of Hepatocyte Like Cells From Immortalized Mouse Embryonic Fibroblasts Harboring Lar... 27/11/2015 - 29/11/2015
    11  A novel khellin molecule with high anti-growth activity in cancer cells... 18/05/2015 - 19/05/2015
    12  New Calcium Channel Blocker Compounds With Anticancer Activity... 18/05/2015 - 19/05/2015
    13  A study on synthesis and anticancer activity comparison of novel thiazole derivatives... 05/05/2015 - 06/05/2015
    14  Investigation of anticancer potential and histone deacetylase inhibitor activity of novel piperaziny... 13/11/2014 - 15/11/2014
    15  New flavonyl-thiazolidinedione compounds against hepatocellular carcinoma cells: identification and ... 21/03/2013 - 23/03/2013
    16  TGF-beta induces senescence in epithelial-like hepatocellular carcinoma cells... 21/05/2009 - 24/05/2009
    17  Downregulation and the anti-growth effect of Zeb2 in hepatocellular carcinoma... 21/05/2009 - 24/05/2009
    18  Molecular Mechanisms of TGF-beta-induced senescence in hepatocellular carcinoma... 29/10/2008 - 01/11/2008
    19  TGF-beta induces p53/Rb-independent, but oxidative stress-dependent cellular senescence in hepatocel... 05/10/2007 - 07/10/2007
    20  SMAD interacting protein 1 (SIP-1) acts as a negative regulator of growth in hepatocellular carcinom... 05/10/2007 - 07/10/2007
    21  Senescence induction as a potential therapeutic strategy in hepatocellular carcinoma... 13/09/2007 - 16/09/2007
    22  Induction of senescence as a potential therapeutic strategy in hepatocellular carcinoma... 09/07/2007 - 10/07/2007
    23  Role of TGF-beta and ROS signaling pathways in hepatocellular senescence... 24/03/2007 - 26/03/2007
    24  Role of SMAD interacting protein 1 in reprogramming of replicative senescence... 24/03/2007 - 26/03/2007
    25  Induction of replicative senescence in hepatocellular carcinoma cells... 24/06/2006 - 29/06/2006
    26  Role of TGF-beta signaling in hepatocellular senescence.... 24/06/2006 - 29/06/2006
    27  Wnt/-beta-catenin signalling is repressed in poorly differentiated hepatocellular carcinoma cells... 24/06/2006 - 29/06/2006
    28  Phylogenetic analysis and expression profiling of TFDP1 and TFDP1L in zebrafish.... 24/06/2006 - 29/06/2006
    29  Molecular pathogenesis of liver cancer... 24/06/2006 - 29/06/2006
    30  Identification of novel genes differentially expressed in beta-catenin/TCF4-activated hepatocellular... 24/06/2006 - 29/06/2006
    31  Characterization of TGF-beta-induced Early Senescence in Hepatocellular Carcinoma Cell Lines... 26/03/2006 - 31/03/2006
    32  Expression profiling of Wnt pathway genes in breast cancer... 22/06/2005 - 26/06/2005
    33  alpha-fetoprotein-producing hepatocellular carcinomas act in vitro as liver stem-like cells.... 29/03/2003 - 02/04/2003
    34  . p53 mutations as fingerprints of environmental carcinogens.... 06/11/2000 - 10/11/2000
    35  p53 tumor suppressor gene - Its role in DNA damage response and cancer... 14/10/1999 - 24/10/1999
    36  p53 as a potential target in cancer-therapy... 05/01/1992 - 08/01/1992
    37  Progress in the immunochemistry of human chorionic-gonadotropin.... 14/07/1988 - 15/07/1988
  • NO CHAPTER TITLE YEAR
    1  Molecular Mechanisms of Hepatocellular Carcinoma Hepatocellular Carcinoma Diagnosis and Treatment...  2016
    2  Molecular Biology of Liver Cancer Encyclopedia of Molecular Cell Biology and Molecular Medicine...  2005
    3  Biology of Hepatocellular Cancer Gastrointestinal Cancers: Biology, Diagnosis and Therapy...  2003
    4  Advances in DNA damage and repair: oxygen radical effects, cellular protection, and biological consequences p53 Tumor Suppressor Gene: Its Role in DNA Damage Response and Cancer...  1999
    5  Molecular Biology of Liver Cancer Encylopedia of Molecular Biology and Molecular Medicine...  1996
    6  Molecular Biology of Liver Cancer Molecular Biology and Biotechnology - A Comprehensive Desk Reference...  1995
    7  Biology of Hepatocellular Carcinoma Gastrointestinal Cancers: Biology, Diagnosis and Therapy...  1995
    8  Chromosomal aberrations and tumor suppressor genes in primary liver cancer Etiological and Progression Factors of Human Hepatocellular Carcinoma...  1994
    9  Free Subunits of Human Chorionic Gonadotropin as Markers of Trophoblastic Differentiation and Malignancy Structure-Function Relationship of Gonadotropins-Serono Symposia Publications from Raven Press...  1989
    10  Monoclonal antibodies directed towards unique epitopes on human chorionic gonadotropin: a new approach to the development of sensitive and specific radioimmunoassays Monoclonal Antibodies and New Trends in Immunoassays...  1988
  • NO NAME DATE
    1  AXL'in KARACİĞER KANSERİN'DEKİ ROLÜ...  11/2017 - /
    2  Türkiyede akraba evliliklerine baglı nörogenetik hastalık yükünün arastırılmasında yeni genomik yaklasımlar...  12/2016 - /
    3  İzmir Sağlık Teknolojileri Geliştirici ve Hızlandırıcısı (Bioİzmir) Projesi...  3/2015 - 6/2016
    4  Karaciğer Kanserinde Hücre Yaşlanmasından Kaçışta Görev Alan Yeni Genlerin Rollerinin Belirlenmesi...  9/2014 - 9/2017
    5  Role of p73 and its miRNA targets in chemosensitivity of liver cancer...  2/2014 - /
    6  Mavi Gen...  9/2014 - 9/2017
  • NO NAME DATE
    1  ? Koç Award for Health Sciences (2004) to the Department of Molecular Biology and Genetics of Bilk...  2004
    2  TÜBİTAK-TWAS Bilim Ödülü...  1995
    3  Cecile Cerveux Cancer Research Award...  1992
  • NO Responsibility
    1 Bioizmir Uluslararasi Sağlik Teknolojileri Geliştirici Ve Hizlandirici Uygulama Ve Araştirma Merkezi , Member of The Central Board, October 2017- February 2018
    2 İzmir Biyotip Ve Genom Uygulama Ve Araştirma Merkezi , Member of The Central Board, May 2017- March 2018
    3 İzmir Biyotip Ve Genom Uygulama Ve Araştirma Merkezi , Center Director, October 2016- March 2018
    4 İzmir Biyotip Ve Genom Uygulama Ve Araştirma Merkezi , Head of The Central Board, October 2016- March 2018
    5 Teaching Hospital , Vice Head Doctor, August 2015- August 2016
    6 Biyotip Ve Sağlik Teknolojileri Anabilim Dali , Director of Science Branch, June 2015- February 2018
    7 İzmir Uluslararasi Biyotip Ve Genom Enstitüsü , Director of The Institute, March 2015- February 2018
    8 İzmir Uluslararasi Biyotip Ve Genom Enstitüsü , Head of The Institute Council, March 2015- February 2018
    9 İzmir Uluslararasi Biyotip Ve Genom Enstitüsü , Head of The Institute Council, March 2015- February 2018
    10 İzmir Biyotip Ve Genom Uygulama Ve Araştirma Merkezi , Center Director, October 2013- October 2016
    11 İzmir Biyotip Ve Genom Uygulama Ve Araştirma Merkezi , Head of The Central Board, October 2013- October 2016
    12 Teaching Hospital , Vice Head Doctor, September 2013- August 2015
    13 Presidency of Dokuz Eylul University Rektörlük , Biyotıp Ve Genom Çalışmaları Koordinatörü, August 2013- December 2014