Academic Staff - Personal Page

Academic Staff - Personal Page

Associate Professor MUHAMMED KASIM DİRİL FACULTY OF MEDICINE BASIC MEDICAL SCIENCES DEPARTMENT OF MEDICAL BIOLOGY

 kasim.diril@deu.edu.tr
 +90 232 - -

Education/Academic Info
Undergraduate Degree	Boğaziçi University Fen-Edebiyat Fakültesi Moleküler Biyoloji ve Genetik	2000
PhD (Doctorate)	Georg-August-Universitat Göttingen Georg-August-Universitat Göttingen Moleküler Biyoloji Anabilim Dalı	2005
Assistant Professor	Dokuz Eylül University Tıp Fakültesi	2014
Associate Professor	Moleküler Biyoloji ve Genetik	2017

NO	NAME	YEAR
1	Development of a mouse embryonic stem cell model for investigating the functions of the linker histo...	2023
2	Genetic dissection of the Mastl-Arpp19/ENSA-PP2A-B55delta pathway in mammalian cells...	2023
3	Genetic complementation screening and molecular docking give new insight on phosphorylation-dependen...	2022
4	How Far Are We from the Rapid Prediction of Drug Resistance Arising Due to Kinase Mutations?...	2021
5	Premature activation of Cdk1 leads to mitotic events in S phase and embryonic lethality...	2018
6	Emi2 Is Essential for Mouse Spermatogenesis...	2017
7	Inhibitory phosphorylation of Cdk1 mediates prolonged prophase I arrest in female germ cells and is ...	2016
8	Loss of the Greatwall Kinase Weakens the Spindle Assembly Checkpoint...	2016
9	Cdk2 catalytic activity is essential for meiotic cell division in vivo....	2016
10	Mastl is required for timely activation of APC/C in meiosis I and Cdk1 reactivation in meiosis II...	2014
11	Identification of transcriptional and metabolic programs related to mammalian cell size...	2014
12	Compromised fidelity of endocytic synaptic vesicle protein sorting in the absence of stonin 2...	2013
13	Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replicatio...	2012
14	Lysosomal localization of GLUT8 in the testis--the EXXXLL motif of GLUT8 is sufficient for its intra...	2009
15	Stonin 2 is an AP-2-dependent endocytic sorting adaptor for synaptotagmin internalization and recycl...	2006
16	Functional dissection of the interactions of stonin 2 with the adaptor complex AP-2 and synaptotagmi...	2004
17	Human stoned B interacts with AP-2 and synaptotagmin and facilitates clathrin-coated vesicle uncoati...	2001

NO	NAME	DATE
1	Transgenik fare modelleri...	30/11/2023 - 01/12/2023
2	Transgenik hayvan modelleri...	29/11/2023 - 01/12/2023
3	Generation and Phenotypic Characterization of a Transgenic Mouse Model for a Neurodevelopmental Rare...	08/07/2023 - 12/07/2023
4	Generation of Transgenic Mouse Models by Electroporation of Cas9/sgRNA Ribonucleoprotein Particles i...	09/12/2021 - 11/12/2021
5	CRISPR genom mühendisliği ile zigot evresi embriyolardan transgenik fare modellerinin üretimi...	28/10/2021 - 31/10/2021
6	Memeli Mastl kinazın aktivasyon mekanizmasının temellerinin saptanması...	28/10/2021 - 31/10/2021
7	Analysis of Mitotic Functions of Mastl Kinase...	05/09/2018 - 08/09/2018
8	Loss of the Mastl kinase weakens the spindle assembly checkpoint...	14/12/2016 - 14/12/2016
9	Targeting cell cycle in liver tumors...	25/06/2015 - 26/06/2015
10	Regulation of mitosis by kinases...	22/05/2015 - 22/05/2015
11	A conditional knockout mouse model uncovers essential roles of Cdk1 in the mammalian cell cycle and ...	10/09/2014 - 12/09/2014
12	In vivo analysis of mitotic kinase functions using mouse models...	27/06/2014 - 27/06/2014
13	Plastic modulation of neurotransmission by endocytic sorting of synaptic vesicle proteins...	14/04/2012 - 18/04/2012
14	Analysis of Cdk1 function in cell cycle using a conditional knock-out mouse model...	04/02/2011 - 04/02/2011
15	Loss of Cdk1 in liver cancer...	17/08/2010 - 21/08/2010

NO CHAPTER TITLE YEAR

1 Molecular Mechanisms of Hepatocellular Carcinoma Hepatocellular Carcinoma Diagnosis and Treatment... 2016

NO	NAME	DATE
1	Türk toplumunda görülen nadir bir nörogenetik hastalık için knockin fare modeli geliştirilmesi ve temel fenotipik karakterizasyonu: TRAPPC4 mutasyonu...	1/2024 - /
2	Rahman sendromu için genetik olarak insanlaştırılmış bir fare modelinin geliştirilmesi ve fenotipik karakterizasyonu...	1/2024 - /
3	İnsanlaştırılmış karaciğer modeli FRG knockout farelerin üretimi ...	8/2023 - /
4	Korunma Ve Tedavi Ulusal Platformu...	2/2023 - /
5	Nörogelişimsel Bir Nadir Genetik Hastalık Için Transgenik Fare Modeli Geliştirilmesi Ve Fenotipik Karakterizasyonu: Atg9b Mutasyonu...	7/2022 - /
6	Sağlıkta ve Rahman Sendromunda Bağlayıcı Histon H1E...	10/2022 - /
7	Transgenik fare modellerinin yerel üretimi için yöntem geliştirilmesi...	10/2020 - 9/2022
8	Pankreas Kanserinin Glutaminaz İnhibisyonuna Duyarlılığında 6-Fosfofrukto-2-Kinaz/Fruktoz-2,6-Bisfosfataz-2'nin Etkisinin Araştırılması...	11/2019 - 5/2022
9	ENSA ve Arpp19 Proteinlerinin Mitotik Fonksiyonlarının İncelenmesi...	7/2018 - 7/2019
10	Mastl kinazın mitotik fonksiyonlarının kimyasal genetik yöntemlerle analizi...	7/2016 - 7/2017
11	Farelerde kuyruk toplardamarından DNA enjeksiyonu ve CRISPR/CAS9 genom mühendisligi yöntemleriyle karaciger kanserinin modellenmesi...	6/2015 - 6/2017

NO	NAME	DATE
1	Bilim Akademisi Genç Bilim İnsanları Ödül Programı, BAGEP...	2016
2	TÜBA ÜSTÜN BAŞARILI GENÇ BİLİM İNSANLARINI ÖDÜLLENDİRME PROGRAMI, GEBİP...	2017

NO NAME YEAR

1 TÜBİTAK BİDEB 2015