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Associate Professor CAN KÜÇÜK FACULTY OF MEDICINE BASIC MEDICAL SCIENCES DEPARTMENT OF MEDICAL BIOLOGY

 can.kucuk@deu.edu.tr
 +90 232 - -

Education/Academic Info
Undergraduate Degree	Middle East Technical University Fen Edebiyat Fakültesi Moleküler Biyoloji ve Genetik	2005
PhD (Doctorate)	The University of Nebraska , Kanser Biyolojisi ve Onkoloji	2012
Assistant Professor	Dokuz Eylül University Tıp Fakültesi	2015
Associate Professor	Dokuz Eylül University Tıp Fakültesi Tıbbi Biyoloji	2018

NO	NAME	YEAR
1	Computer-Aided Identification and Design of Ligands for Multi-Targeting Inhibition of a Molecular Ac...	2024
2	Potential diagnostic and prognostic biomarkers of pediatric Burkitt lymphoma identified through miRN...	2024
3	Whole exome sequencing reveals genetic variants in low-risk and high-risk neuroblastoma...	2023
4	Genetic and epigenetic analyses reveal transcriptional silencing of SOX7 due to deletion in a multip...	2023
5	New insights into epigenetic regulation of resistance to PD-1/PD-L1 blockade cancer immunotherapy: m...	2022
6	Whole Transcriptome Sequencing Reveals Cancer-Related, Prognostically Significant Transcripts and Tu...	2022
7	Plasma Concentrations and Cancer-Associated Mutations in Cell-Free Circulating DNA of Treatment-Naiv...	2022
8	In Silico Methods for the Identification of Diagnostic and Favorable Prognostic Markers in Acute Mye...	2021
9	PRDM1 decreases sensitivity of human NK cells to IL2-induced cell expansion by directly repressing C...	2021
10	A prognostic model for melanoma patients on the basis of immune-related lncRNAs...	2021
11	Indolent T-Cell Lymphoproliferative Disease of the GI Tract: Insights for Better Diagnosis, Prognosi...	2020
12	Genetic susceptibility to natural killer T-cell lymphoma...	2020
13	Epigenetic aberrations in natural killer/T-cell lymphoma: diagnostic, prognostic and therapeutic imp...	2020
14	Genetic alterations in B cell lymphoma subtypes as potential biomarkers for noninvasive diagnosis, p...	2020
15	Systematic analysis of the frequently amplified 2p15-p16.1 locus reveals PAPOLG as a potential proto...	2019
16	Primary cardiac diffuse large B-cell lymphoma with concurrent high MYC and BCL2 expression in an imm...	2017
17	Whole transcriptome analysis reveals dysregulated oncogenic lncRNAs in natural killer/T-cell lymphom...	2017
18	The relationship of REL proto-oncogene to pathobiology and chemoresistance in follicular and transfo...	2017
19	Clinicopathologic Characterization of Aggressive Natural Killer Cell Leukemia Involving Different Ti...	2016
20	Diagnostic and Biological Significance of KIR Expression Profile Determined by RNA-Seq in Natural Ki...	2016
21	Generation of a genetically engineered aggressive NK-cell leukemia cell line with stable IL2 express...	2015
22	Global promoter methylation analysis reveals novel candidate tumor suppressor genes in natural kille...	2015
23	Lack of Evidence that HACE1 Is Not a Tumor Suppressor Gene in NKTCL: To the Editor-in-Chief...	2015
24	Activating mutations of STAT5B and STAT3 in lymphomas derived from ??-T or NK cells...	2015
25	Genome-wide copy number analyses reveal genomic abnormalities involved in transformation of follicul...	2014
26	Indolent T-cell lymphoproliferative disease of the gastrointestinal tract...	2013
27	MicroRNA expression profiling identifies molecular signatures associated with anaplastic large cell ...	2013
28	HACE1 is a Tumor Suppressor Gene Candidate in Natural Killer Cell Neoplasms...	2013
29	IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma...	2012
30	PRDM1 is a Tumor Suppressor Gene in Natural Killer Cell Malignancies...	2011
31	NK-cell lymphoma shares strikingly similar molecular features with a distinct subset of T-cell lymph...	2011
32	Synaptic Development of the Mouse Dorsal Geniculate Nucleus...	2010
33	Molecular signatures to improve diagnosis in peripheral T-cell lymphoma and prognostication in angio...	2010
34	Genomic analyses reveal global functional alterations that promote tumor growth and novel tumor supp...	2009
35	Clinical implication of genome-wide profiling in diffuse large B-cell lymphoma and other subtypes of...	2007

NO	NAME	DATE
1	SOX7 Transkripsiyon Faktörünün Multipl Miyelomdaki Rolünün Moleküler, Epigenomik ve Transkript...	31/10/2024 - 02/11/2024
2	Genomic analyses of circulating cell-free DNA in follicular lymphoma: diagnostic, prognostic, and th...	17/10/2024 - 19/10/2024
3	Potential diagnostic and progrnostic biomarkers of pediatric Burkitt lymphoma identified through miR...	13/06/2024 - 16/06/2024
4	PRDM1 Promotes Primary Human Circulating CD56dim NK-Cell Differentiation...	09/12/2023 -
5	Genetik ve epigenetik olarak sessizleşen SOX7'nin multipl miyelomdaki tümör baskılayıcı gen...	02/11/2023 -
6	SOX7 is a candidate tumor suppressor gene in multiple myeloma...	17/08/2023 - 19/08/2023
7	SOX7 tümör baskılayıcı adayı iki kez nükseden multipl miyelom olgusu tümörlerinde genetik o...	04/11/2021 - 07/11/2021
8	Ultra-Deep Targeted Sequencing Reveals Cancer-Associated, Prognostically Significant Mutations in Ci...	05/12/2020 - 08/12/2020
9	CD25 (IL2RA) Is a Direct Transcriptional Target of PRDM1 in Activated Human Natural Killer Cells...	01/12/2018 - 04/12/2018
10	Foliküler lenfoma dolaşımsal serbest DNA'sının invazif olmayan tanı amaçlı genomik profil an...	01/11/2018 - 03/11/2018
11	Doğal öldürücü/T hücre lenfomalarında tüm transkriptom analizi sonucu disregüle olan kanser...	26/10/2017 - 29/10/2017
12	THE ROLE OF REL PROTO ONCOGENE IN FOLLICULAR LYMPHOMA DEVELOPMENT...	27/10/2016 - 20/10/2016
13	Lenfoid Kanser Genomiği...	27/06/2016 -
14	Functional genomics of NK and gamma-delta T cell lymphomas: therapeutic and diagnostic implications...	17/02/2016 -
15	STAT5B ve STAT3 sürücü mutasyonları gamma delta T ve doğal öldürücü hücrelerden türeyen p...	27/10/2015 - 30/10/2015
16	RNA-Seq analysis reveals KIR2DL4 expression as a clonal diagnostic marker and potential therapeutic ...	17/10/2015 -
17	Frequent Activating Mutations Of JAK-STAT Pathway Genes In Natural Killer Cell Lymphomas...	10/12/2013 -
18	Global Methylation Analysis Reveals Novel Candidate Tumor Suppressor Genes In Natural Killer Cell Ly...	07/12/2013 -
19	Genetic Abnormalities in Follicular Lymphoma and Transformed Follicular Lymphoma...	08/12/2012 - 11/12/2012
20	NK-Cell Lymphoma Shares Strikingly Similar Molecular Features with a Distinct Set of gamma-delta T-C...	05/12/2009 - 08/12/2009
21	Genomic Analyses Reveal Global Functional Alterations That Promote Tumor Growth and Novel Tumor Supp...	08/12/2008 -
22	Molecular Signatures to Improve Diagnosis, Prognostication and Identification of Oncogenic Pathways ...	05/12/2008 - 08/12/2008

NO	CHAPTER TITLE	YEAR
1	Genomics and Epigenomics of Natural Killer/T Cell Lymphoma: Diagnostic, Prognostic, and Therapeutic ImplicationsInterdisciplinary Cancer Research...	2024
2	Genomik ve UygulamalarıMoleküler Biyoloji ve Genetik - Sağlık Alanında ve Biyoteknolojide İleri Uygulamalar...	2023
3	Lenfoma Genetiği (HL, NHL, B-cell lenfoma, KLL) HematoLog...	2019

NO	NAME	DATE
1	Pediatrik Burkitt Lenfoma Hastalarında Dolaşımsal Serbest ve Ekzozomal MikroRNA İfade Seviyelerinin İnvazif Olmayan Tanı Biyobelirteci Olma Potansiyellerinin İncelenmesi....	11/2018 - 5/2022
2	Türkiyede akraba evliliklerine baglı nörogenetik hastalık yükünün arastırılmasında yeni genomik yaklasımlar...	12/2016 - 6/2020

NO	NAME	DATE
1	ASH Uluslararası Sosyal Destek İnisiyatifi...	2024
2	ASH Uluslararası Sosyal Destek İnisiyatifi...	2023
3	Amerika Hematoloji Derneği (ASH) Takviye Ödülü...	2021
4	46.Ulusal Hematoloji Kongresi Ulusal Kongre Bildiri Ödülü...	2020
5	Onkolojide İz Bırakanlar Makale Ödülü...	2019
6	Uluslarararası Genç Bilim İnsanı Ödülü...	2018
7	Amerika Hematoloji Derneği Küresel Araştırma Ödülü...	2018
8	Genç Araştırmacı Birincilik Ödülü...	2017
9	TÜBA-Üstün Başarılı Genç Bilim İnsanlarını Ödüllendirme Programı (TÜBA-GEBİP)...	2017
10	Genç Bilim İnsanı ödülü (BAGEP)...	2015
11	Amerika Hematoloji Derneği Çalışma Özeti Başarı Ödülü...	2013

NO	NAME	YEAR
1	Avrupa Hematoloji Topluluğu (EHA)	2018
2	Türkiye Bilimsel ve Teknolojik Araştırma Kurumu	2002